Radon and COPD mortality in the American Cancer Society Cohort
Authored by: Michelle C. Turner, Daniel Krewski, Yue Chen, C. Arden Pope III,
Susan M. Gapsture and Michael J. Thune
Abstract: Although radon gas is a known cause of lung cancer, the association between residential radon and mortality from non-malignant respiratory disease has not been well characterised.
The Cancer Prevention Study-II is a large prospective cohort study of nearly 1.2 million Americans recruited in 1982. Mean county-level residential radon concentrations were linked to study participants’ residential address based on their ZIP code at enrolment (mean¡SD
53.5¡38.0 Bq?m-3). Cox proportional hazards regression models were used to estimate adjusted
hazard ratios (HR) and 95% confidence intervals (CI) for non-malignant respiratory disease
mortality associated with radon concentrations. After necessary exclusions, a total of 811,961